Key result
Novel human T-cell cyclophilin hCyP33 uniquely combines RNA binding and protein folding.
Why the study?
Cyclophilins are known to bind cyclosporins and proteins, but a nuclear cyclophilin with RNA-binding capability in human T cells had not been described.
Population
Human T cells
Design
Molecular characterization study
Authors
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May link RNA regulation to protein folding in T cells; leaves open any role in cardiac immunology or immunosuppression.
Key points are not available for this paper at this time.
Mi et al. (1996) studied this question. A novel nuclear cyclophilin (hCyP33) with an RNA-binding domain was identified in human T cells, combining RNA binding and protein folding in one protein for the first time.
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