Editorial: Mechano-Calcium, Mechano-Electric, and Mechano-Metabolic Feedback Loops: Contribution to the Myocardial Contraction in Health and Diseases

Mechano-Calcium, Mechano-Electric, and Mechano-Metabolic Feedback Loops: Contribution to the Myocardium Contraction in Health and DiseasesSensing of and adaptation to mechanical forces in the heart are allowed in part by Mechano-Electric Coupling (MEC), including mechano-electric, -calcium, and -mechanical feedback mechanisms interrelating with each other.Mechanosensitivity of healthy and diseased hearts has been a focus of research interests for decades (Lab, 1982(Lab, , 1996(Lab, , 1999;;Kohl et al., 1999;Kohl and Sachs, 2001;Takahashi et al., 2013).Many mechanisms underlying MEC are still unclear.The works presented in this Research Topic involve state-of-the-art experimental approaches, computational modeling and focused reviews, aimed at shedding light on some specific aspects of MEC which can be subdivided as follow. MEC AND CARDIAC REMODELINGCardiac metabolic, mechanical, electrical, and structural remodeling allows the heart to adapt its function to the demand.Such plasticity of the cardiac tissue and cells in response to hemodynamic loads is comprehensively reviewed by Pitoulis and Terraciano.Two more articles presented in the Research Topic also relate to remodeling (Abu-Khousa et al., Seo et al.). FRANK-STARLING LAW AND UNDERLYING MECHANISMSThree articles deal with "Force-Length" and "Pressure-Volume" relationships in single cardiomyocytes, multicellular preparations, and whole ventricle.Using a mathematical model of cardiac excitation-contraction, Guidry et al. compared end-systolic force-length relationships (ESFLR) simulated in isometric and work-loop contractions.These simulations show that the isometric ESFLR curve lies significantly higher than its work-loop counterpart, being in good