Key result
Multilayer flow modulators linked to ~145% increase in true lumen volume for type B aortic dissections.
Why the study?
Multilayer stents have been proposed to improve flow dynamics and preserve branch vessel patency in type B aortic dissections, but standardized protocols to investigate aortic remodeling are needed.
Does intervention with multilayer flow modulators improve geometric and hemodynamic parameters of aortic remodeling in patients with type B aortic dissections?
Cohort (n=16)
No
Does intervention with multilayer flow modulators improve geometric and hemodynamic parameters of aortic remodeling in patients with type B aortic dissections?
Absolute Event Rate: 174.17% vs 71.09%
p-value: p=<0.001
Multilayer flow modulators for type B aortic dissection significantly improve geometric and hemodynamic parameters of aortic remodeling, including increased true lumen volume and decreased false lumen volume.
Recently, multilayer stents for type B aortic dissections (TBAD) have been proposed to decrease false lumen flow, increase and streamline true lumen flow, and retain branch vessel patency. We aimed to provide a protocol with standardized techniques to investigate aortic remodeling of TBAD by multilayer flow modulators (MFM) in static geometric and hemodynamic analyses. Combining existing literature and new insights, a standardized protocol was designed. Using pre- and postoperative CT scans, geometric models were constructed, lumen dimensions were calculated, computational fluid dynamics (CFD) models were composed, and velocity and pressures were calculated. Sixteen TBAD cases treated with MFM were included for analysis. For each case, aortic remodeling was analyzed using post-processing medical imaging software. After 3D models were created, geometrical anatomical measurements were performed, and meshes for finite element analysis were generated. MFM cases were compared pre- and postoperatively; true lumen volumes increased (p < 0.001), false lumen volumes decreased (p = 0.001), true lumen diameter at the plane of maximum compression (PMC) increased (p < 0.001), and false lumen index decreased (p = 0.008). True lumen flow was streamlined, and the overall fluid velocity and pressures decreased (p < 0.001 and p = 0.006, respectively). This protocol provided a standardized method to evaluate the effects of MFM treatments in TBAD on geometric analyses, PMC, and CFD outcomes.
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Costache et al. (2020) conducted a cohort in Type B aortic dissections (TBAD) (n=16). Multilayer flow modulator (MFM) stents vs. Preoperative baseline was evaluated on Median true lumen volume at latest follow-up (cm3) (p=<0.001). Endovascular treatment of type B aortic dissections with multilayer flow modulator stents significantly increased median true lumen volume from 71.09 cm3 to 174.17 cm3 and decreased false lumen volume.
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