Key result
Induced sputum detects amiodarone and inflammatory cells in 75% of amiodarone-associated ILD cases.
Why the study?
Amiodarone may cause pulmonary injury including chronic interstitial lung diseases in 5-15% of patients, and non-invasive diagnostic methods are needed.
Does induced sputum help diagnose amiodarone-induced pulmonary toxicity in patients with ischemic heart diseases?
Case Report (n=4)
Does induced sputum help diagnose amiodarone-induced pulmonary toxicity in patients with ischemic heart diseases?
Answers are grounded in this paper and cite their sources.
Induced sputum may be a useful, non-invasive tool for assessing amiodarone toxicity in patients with ischemic heart diseases and concomitant pulmonary side effects.
Amiodarone, a highly effective medication for suppressing cardiac rhythm disturbances, may cause pulmonary injury, such as chronic interstitial lung diseases, in 5-15% of the patients who take it. We applied induced sputum (IS), a non-invasive technique, for diagnosing amiodarone-induced pulmonary toxicity. Four patients with interstitial lung disease who were treated by amiodarone for ischemic heart diseases were evaluated by a conventional clinical workup. All four patients showed marked interstitial pattern on computerized tomography and decreased diffusion capacity (DLCO-SB 51-76%). IS showed lymphocytosis, a high CD4 or CD8 count, eosinophilia and amiodarone in 3 of 4 patients. IS may be a useful tool for assessing amiodarone toxicity in patients with ischemic heart diseases and concomitant pulmonary side effects.
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Fireman et al. (2006) conducted a case report in Amiodarone-associated interstitial lung disease (n=4). Induced sputum was evaluated on Presence of lymphocytosis, high CD4 or CD8 count, eosinophilia, and amiodarone in induced sputum. Induced sputum revealed lymphocytosis, high CD4 or CD8 count, eosinophilia, and amiodarone in 75% (3 of 4) of patients with amiodarone-associated interstitial lung disease.
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