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Investigate the histopathologic features, cellular localization, and distribution of SARS-CoV-2 in tissue specimens from fatal COVID-19 cases.

May 21, 2020Emerging infectious diseasesOpen Access

Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States

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Investigate the histopathologic features, cellular localization, and distribution of SARS-CoV-2 in tissue specimens from fatal COVID-19 cases.
Examined postmortem tissue specimens from confirmed fatal cases of COVID-19 (N=8) in the United States.
Evaluated tissue histopathology and detected viral distribution using immunohistochemistry (IHC) and electron microscopy (EM).
Characterized histopathologic injury patterns and viral presence across target tissues in fatal infections.
Localized SARS-CoV-2 in lower respiratory tract tissues via IHC and EM to elucidate mechanisms of fatal coronavirus disease.

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Implication

Autopsy series uncovers tissue pathology and viral localization in fatal COVID-19 cases, highlighting mechanisms of severe lower respiratory tract disease.

Cite This Study

Martines et al. (2020) studied this question.

synapsesocial.com/papers/6aab4860f44a66025f457ab7 https://doi.org/10.3201/eid2609.202095

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Implication

Autopsy series uncovers tissue pathology and viral localization in fatal COVID-19 cases, highlighting mechanisms of severe lower respiratory tract disease.

Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States

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Discussion

Implication

Cite This Study

Pathology and Pathogenesis of SARS-CoV-2 Associated with Fatal Coronavirus Disease, United States

Key Points

Discussion

Implication

Cite This Study

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