Key result
Infant enterovirus meningitis is linked to early rising CSF IL-6, free radicals, and viral loads.
Why the study?
The role of viral load, free radicals, and cytokines in viral meningitis in infants below 1 year of age was not well understood.
Population
Infants below 1 year of age with enterovirus-positive CSF
Design
Observational survey of CSF samples
Authors
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May aid early diagnosis of enteroviral meningitis in infants lacking pleocytosis; leaves open validation before clinical adoption.
Observational
IL-6 and free radicals in CSF may serve as early diagnostic markers for viral meningitis in infants before pleocytosis occurs.
Kawashima et al. (2008) conducted an observational in Enterovirus meningitis. Viral load, free radicals, and IL-6 levels was evaluated on Levels of IL-6, free radicals, and viral loads in cerebrospinal fluid. In infants with enterovirus meningitis, CSF levels of IL-6 and free radicals increased early in the disease course, with viral loads and free radicals increasing simultaneously.
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