A randomized clinical trial evaluating the efficacy of the sandwich bone augmentation technique in increasing buccal bone thickness during implant placement. II . Tomographic, histologic, immunohistochemical, and RNA analyses

Q: What is the clinical evidence from this study?

Study design: RCT. Population: buccal implant dehiscence defects (n=26). Intervention: Bovine pericardium membrane over bone graft (sandwich bone augmentation) vs. Bone graft without membrane. Primary outcome: Biologic and structural phenotypes of regenerated bone (bone volume and tissue maturation).

Jia Fu; Héctor F. Ríos; Khalid Al‐Hezaimi; Tae‐Ju Oh; Erika Benavides; Hom‐Lay Wang

doi:10.1111/clr.12481

September 15, 2014Clinical Oral Implants Research

A randomized clinical trial evaluating the efficacy of the sandwich bone augmentation technique in increasing buccal bone thickness during implant placement. II . Tomographic, histologic, immunohistochemical, and RNA analyses

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Key result

Sandwich bone augmentation maintains bone volume but delays tissue maturation versus graft alone.

n=26

Why the study?

The biologic and structural characteristics of bone regenerated via the sandwich bone augmentation technique on buccal implant dehiscence defects were not well characterized.

Does the sandwich bone augmentation technique with a bovine pericardium membrane improve bone regeneration in patients with buccal implant dehiscence defects?

Study Design

Type

RCT (n=26)

Randomization

randomly assigned

Structured PICO

Does the sandwich bone augmentation technique with a bovine pericardium membrane improve bone regeneration in patients with buccal implant dehiscence defects?

P

Population

26 patients with buccal implant dehiscence defects who received bone grafts, followed for 6 months.

I

Intervention

Mineralized cancellous and cortical allogenic bone graft covered with a bovine pericardium membrane (sandwich bone augmentation technique)

C

Comparator

Mineralized cancellous and cortical allogenic bone graft without a membrane

O

Outcome

Biologic and structural phenotypes of the regenerated bone (evaluated via histologic, immunohistochemical, mRNA, and micro-computed tomography analyses)surrogate

The sandwich bone augmentation technique using a collagen barrier membrane preserves ridge volume but may delay the complete maturation of the outermost layer of the grafted site.

Limitations

Only 12 of the 26 bone core biopsies were suitable for analysis
Only 12 of 26 bone core biopsies were suitable for analysis

Implication

Caution warranted with collagen membranes due to delayed maturation; leaves open long-term implant outcomes in small trials.

Discussion

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Cite This Study

Fu et al. (2014) conducted an RCT in buccal implant dehiscence defects (n=26). Bovine pericardium membrane over bone graft (sandwich bone augmentation) vs. Bone graft without membrane was evaluated on Biologic and structural phenotypes of regenerated bone (bone volume and tissue maturation). Sandwich bone augmentation using a collagen barrier membrane maintained bone volume but delayed tissue maturation compared to graft alone at 6 months (n=12 analyzed).

synapsesocial.com/papers/6aab4a410f97175eec6a4765 https://doi.org/10.1111/clr.12481

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A randomized clinical trial evaluating the efficacy of the sandwich bone augmentation technique in increasing buccal bone thickness during implant placement. II . Tomographic, histologic, immunohistochemical, and RNA analyses

Study Design

Structured PICO

Limitations

Implication

Discussion

Cite This Study

A randomized clinical trial evaluating the efficacy of the sandwich bone augmentation technique in increasing buccal bone thickness during implant placement. II . Tomographic, histologic, immunohistochemical, and RNA analyses

Study Design

Structured PICO

Limitations

Implication

Discussion

Cite This Study

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