Key result
Sublingual nitroglycerine blunts intubation pressor response vs lignocaine but fails to prevent reflex tachycardia.
Why the study?
Laryngoscopy and tracheal intubation cause undesirable hypertension and tachycardia, prompting comparison of nitroglycerine spray versus 10% lignocaine spray for attenuating these hemodynamic responses.
Does nitroglycerine spray reduce hemodynamic responses to laryngoscopy and endotracheal intubation compared to lignocaine spray in ASA I-II patients?
RCT (n=90)
randomly
Does nitroglycerine spray reduce hemodynamic responses to laryngoscopy and endotracheal intubation compared to lignocaine spray in ASA I-II patients?
p-value: p=< 0.05
Nitroglycerine sublingual spray is more effective than lignocaine spray in attenuating the pressor response to laryngoscopy and endotracheal intubation, making it a viable alternative for hemodynamic control.
Nitroglycerine spray may be preferred over lignocaine for attenuating intubation pressor responses in elective cases; extends RCT data on periprocedural hemodynamic options.
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Samuel et al. (2020) conducted an RCT in Patients scheduled for elective surgeries under general anesthesia (n=90). Nitroglycerine (NTG) sublingual spray vs. 10% lignocaine spray 20 mg (2 puffs) 60s before laryngoscopy was evaluated on Hemodynamic responses (HR, SBP, DBP, MAP) to laryngoscopy and endotracheal intubation (p=< 0.05). Nitroglycerine sublingual spray effectively attenuated the pressor response to laryngoscopy and intubation compared to lignocaine spray (P<0.05), though it did not prevent reflex tachycardia.
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