Key result
Endothelial Elavl1 modulates disturbed flow-induced inflammation to regulate immune responses in atherosclerosis.
Endothelial Elavl1 plays a role in fine-tuning immune responses in atherosclerosis.
Atherosclerotic plaques arise preferentially at arterial sites exposed to low and disturbed flow, where endothelial cells (ECs) adopt a proinflammatory and dysfunctional phenotype.1- 4 The endothelium has therefore long been viewed as both a selective barrier and a
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Cowan et al. (2026) studied this question. Endothelial Elavl1 fine-tunes immune responses in atherosclerosis, modulating the proinflammatory and dysfunctional phenotype of endothelial cells exposed to disturbed flow.
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