Key result
Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in high-fat diet mice.
Why the study?
The effects of vitamin B6 in metabolic syndrome are poorly understood.
Does Vitamin B6 prevent endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe (-/-) mice fed with high-fat diet?
Does Vitamin B6 prevent endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe (-/-) mice fed with high-fat diet?
Vitamin B6 supplementation prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in a mouse model of metabolic syndrome.
May support VitB6 investigation in metabolic syndrome; leaves open clinical translation from this preclinical model.
Backgrounds. VitB6 deficiency has been associated with a number of adverse health effects. However, the effects of VitB6 in metabolic syndrome are poorly understood. Methods. VitB6 (50 mg/kg/day) was given to Apoe (-/-) mice with hkdigh-fat diet (HFD) for 8 weeks. Endothelial dysfunction, insulin resistance, and hepatic lipid contents were determined. Results. VitB6 administration remarkably increased acetylcholine-induced endothelium-dependent relaxation and decreased random blood glucose level in Apoe (-/-) mice fed with HFD. In addition, VitB6 improved the tolerance of glucose and insulin, normalized the histopathology of liver, and reduced hepatic lipid accumulation but did not affect the liver functions. Clinical and biochemical analysis indicated that the levels of VitB6 were decreased in patients with fatty liver. Conclusions. Vitamin B6 prevents endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe (-/-) mice fed with HFD. Supplementation of VitB6 should be considered to prevent metabolic syndrome.
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Liu et al. (2015) studied Metabolic syndrome. Vitamin B6 was evaluated on Endothelial dysfunction, insulin resistance, and hepatic lipid contents. Vitamin B6 administration (50 mg/kg/day) for 8 weeks prevented endothelial dysfunction, insulin resistance, and hepatic lipid accumulation in Apoe (-/-) mice fed a high-fat diet.
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