Review: major anxiety disorders all have substantive familial aggregation

This is the authors' abstract. We don't add key points for this paper.

Hettema JM, Neale MC, Kendler KS. A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry2001 Oct; 158 : 1568 –78 [OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] QUESTION: In major anxiety disorders, what is the contribution of genetics and environment to their aetiology? Studies were identified by searching Medline and by scanning the reference sections of identified studies and reviews. Studies were selected if they used operationalised diagnostic criteria, there was a systematic ascertainment of probands and relatives, a majority of participants were directly interviewed, the diagnostic assessment of relatives was blind to proband affection status, and for family studies there was a comparison group. Data were extracted on study quality, patient characteristics, diagnostic criteria used, and outcome measures. A meta-analysis was used to estimate summary statistics of aggregate familial risk and heritability for each anxiety disorder. 5 family studies of panic disorder met the selection criteria. All 5 … [1]: {openurl}?query=rft.jtitle%253DAmerican%2BJournal%2Bof%2BPsychiatry%26rft.stitle%253DAm.%2BJ.%2BPsychiatry%26rft.aulast%253DHettema%26rft.auinit1%253DJ.%2BM.%26rft.volume%253D158%26rft.issue%253D10%26rft.spage%253D1568%26rft.epage%253D1578%26rft.atitle%253DA%2BReview%2Band%2BMeta-Analysis%2Bof%2Bthe%2BGenetic%2BEpidemiology%2Bof%2BAnxiety%2BDisorders%26rft_id%253Dinfo%253Adoi%252F10.1176%252Fappi.ajp.158.10.1568%26rft_id%253Dinfo%253Apmid%252F11578982%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1176/appi.ajp.158.10.1568&link_type=DOI [3]: /lookup/external-ref?access_num=11578982&link_type=MED&atom=%2Febmental%2F5%2F3%2F92.atom [4]: /lookup/external-ref?access_num=000171374500003&link_type=ISI