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September 20, 2024Psychiatry and Clinical NeurosciencesOpen Access

Identification of novel genomic loci for anxiety symptoms and extensive genetic overlap with psychiatric disorders

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Authors

MTMarkos TesfayePJPiotr JahołkowskiASAlexey Shadrin

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Overview

Genome-wide association study reveals 119 novel risk loci for anxiety symptoms in 397,573 participants, highlighting shared genetic pathways with psychiatric disorders.

Key Points

  • Novel loci numbering 119 associate with anxiety symptoms and show extensive overlap with psychiatric disorders, implicating shared cell adhesion pathways.
  • Conditional and conjunctional false discovery rate analyses boosted locus discovery across 301,732 cohort participants, evaluating cross-trait polygenic architecture.
  • Highlights shared molecular underpinnings that may enable novel drug targets for anxiety, with enriched biological pathways involving neurofibrillary tangle formation.

Cite This Study

Tesfaye et al. (2024) studied this question.

synapsesocial.com/papers/68e57c2ab6db64358751b99ehttps://doi.org/10.1111/pcn.13742
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