Regulating RNA interference by modifying RNA backbone with amides

are using innovative nucleic acid chemistry to modify RNA-based technologies such as RNA interference (RNAi) and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) to enhance their utility in molecular biology.These technologies suffer from off-target effects that limit their clinical utility.By replacing phosphates in the backbone with amides, the team aims to improve the stability, specificity, and uptake of these technologies by cells to make them more suitable for in vivo applications.