Gut-liver axis: physeology through the prism of the microbiome

This paper presents a brief historical description of the evolution of views on the development of the concept of the gut liver axis functioning and its physiological aspects. The “new virtual human organ” physiological fundamentals and their role in the pathogenesis of chronic liver diseases, including late post-transplant period, are described and discussed. Based on own experience, results of a new generation sequencing describing the characteristics of the microbiome palette in patients suffering from chronic liver diseases of various etiologies are presented. Personal study was based on 12 patients suffering chronic liver disease, who were examined before and after liver transplantation. The obtained results indicate the importance of the intestinal microbiome in the natural process of recovery after liver transplantation.