Key result
Asymptomatic picornavirus in the neonatal airway is linked to general up-regulation of immune mediators.
Why the study?
The impact of respiratory viruses on the airway mucosa immune response in asymptomatic neonates was unknown.
Does the asymptomatic presence of picornavirus alter the airway mucosa immune profile in neonates?
Cohort (n=571)
Does the asymptomatic presence of picornavirus alter the airway mucosa immune profile in neonates?
p-value: p=<.0001
Asymptomatic presence of picornavirus in the neonatal airway is a potent activator of the topical immune response, which may explain the immune potentiating effect of early life viral exposure.
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May prime neonatal mucosal immunity; observational data leaves causal effects on later outcomes open.
Wolsk et al. (2015) conducted a cohort in Asymptomatic neonates (n=571). Picornavirus vs. Absence of picornavirus was evaluated on Levels of 20 immune mediators (p=<.0001). Asymptomatic presence of picornavirus in the neonatal airway was associated with a general up-regulation of immune mediators (P < .0001).
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