Key result
Higher COPD severity is linked to significant 5-year 6MWD decline, affecting ~63% in stage IV.
Why the study?
Little is known about the natural long-term change in the 6-min walking distance in patients with COPD.
Cohort (n=294)
The 6-min walking distance test provides increasingly useful information regarding functional decline as the severity of COPD increases.
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6MWD decline may accelerate with COPD severity unlike FEV1; leaves open its added value for monitoring progression in observational cohorts.
Casanova et al. (2006) conducted a cohort in chronic obstructive pulmonary disease (COPD) (n=294). COPD severity was evaluated on Annual rate of decline in 6-min walking distance (6MWD). Over 5 years, the proportion of COPD patients with a clinically significant decline in 6-minute walking distance increased with disease severity (24% in stage II, 45% in stage III, 63% in stage IV).
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