Key result
Circulating chemerin links to obesity markers but not insulin resistance, with higher mRNA expression in women.
Why the study?
Gender- and adipose tissue-specific differences in human chemerin expression have not been well characterized in obesity.
Cross-Sectional
Circulating chemerin levels are associated with obesity markers, and its mRNA expression shows gender and fat depot-specific differential regulation.
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Gender and depot-specific chemerin expression differences observed; leaves open causal links to obesity phenotypes in prospective studies.
Alfadda et al. (2012) conducted a cross-sectional in Obesity. Obesity and gender was evaluated on Correlation of serum chemerin with obesity markers and differential mRNA expression by gender and fat depot. Circulating chemerin levels were associated with obesity markers but not insulin resistance, and chemerin mRNA expression was significantly higher in women and in subcutaneous adipose tissue.