Key result
Composite aortic grafts in Marfan syndrome are linked to ~68% fewer late complications versus other procedures.
Why the study?
Surgical treatment strategies for cardiovascular complications in Marfan syndrome with ascending aortic pathology require evaluation over long-term follow-up.
Does composite graft insertion improve survival and reduce late complications compared to other surgical procedures in patients with Marfan syndrome and ascending aortic pathology?
Comparison
Composite grafts vs other ascending aorta procedures
Design
Cohort study
Follow-up
Mean 6.7 years (range 1-27 years)
Authors
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May favor composite grafts to reduce late complications in Marfan ascending aortic repair; leaves open need for randomized confirmation.
Cohort (n=52)
Does composite graft insertion improve survival and reduce late complications compared to other surgical procedures in patients with Marfan syndrome and ascending aortic pathology?
Absolute Event Rate: 16% vs 50%
Composite graft insertion provides superior long-term survival and freedom from late complications compared to other surgical approaches for ascending aortic pathology in patients with Marfan syndrome.
Carrel et al. (1992) conducted a cohort in Marfan syndrome and ascending aortic pathology (n=52). Composite graft insertion vs. Other procedures on the ascending aorta was evaluated on Incidence of late complications. Composite graft insertion for ascending aortic pathology in Marfan syndrome was associated with a lower incidence of late complications compared to other surgical procedures (16% vs. 50%).
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