⌘+K

Pulse Explore Communities Researchers Journals

Home Communities Explore

July 1, 1992Journal of Medicinal ChemistryOpen Access

Synthesis and antihistaminic activity of some thiazolidin-4-ones

Maria Vittoria Diurno Orazio Mazzoni E Piscopo Antonio Calignano Federico Giordano A. BOLOGNESE

View Full Paper

Ask AI

Bookmark

Share

Abstract

A new series of 2-(4- and 3-substituted phenyl)-3-[3-(N,N-dimethylamino) propyl]-1,3-thiazolidin-4-ones were synthesized, characterized, and evaluated for their ability to inhibit the contractions induced by histamine on guinea pig ileum. The measurement of pA2 values suggested that the reported compounds showed H1-antagonism. The more active compounds 5, 9, and 13 exhibited activity close to that of mepyramine.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Diurno et al. (1992) studied this question.

synapsesocial.com/papers/6aab7d15293d653c6437c204 https://doi.org/10.1021/jm00093a025

View Full Paper

Ask AI

Bookmark

Share

Keep reading

Synapse has enriched 5 related papers. Consider them for comparative context:

1Design and Biological Evaluation of a Potent Dual PARP and BRD4 Inhibitor for Tumor Therapy via Disrupting HRR and BRD4-cJUN-CCL2 AxisJournal of Medicinal Chemistry · Thu,
2Design, Synthesis, and Antifibrotic Evaluation of Silicon-Incorporated Alkyl Hydrazide Analogs of Tubastatin A: HDAC3 Selective Inhibitor for Ameliorating Liver FibrosisJournal of Medicinal Chemistry · Thu,
3Structure-Based Design of 2-(Pyridone)Indoles as Antagonists of the Toll-Like Receptors TLR7 and TLR8 for the Treatment of Autoimmune DisordersJournal of Medicinal Chemistry · Wed,
4Discovery of Novel Orally Bioavailable STING Inhibitors with 4,5,6,7-Tetrahydropyrazolo[1,5- a ]pyrazine Moiety for STING-Mediated Inflammatory DisordersJournal of Medicinal Chemistry · Wed,
5Design, Synthesis, and Biological Evaluation of 1 H -Pyrrolo[3,2- c ]quinolines as Potent and Selective Antitubulin Agents Active against Drug-Resistant Cell LinesJournal of Medicinal Chemistry · Wed,

More from Journal of Medicinal Chemistry

Synthesis, Spectroscopic, Computational, and PDT Investigations of a Series of Cationic Meso -(3-pyridyl)-indolylstyryl-BODIPYsThu,
Discovery of Novel Pyridine-Dihydropyrrolo[3,4- b ]Pyrrolidone Derivatives as Orally Active PIM Kinase Inhibitors for the Treatment of Acute Myeloid LeukemiaThu,
Synthesis and Structure−Activity Relationship (SAR) of Hydroxypyridone-3-carboxamides against OrthopoxvirusesThu,
Imidazo[1,2- a ]pyrazine Derivatives as Dual A2A/A2B Adenosine Receptor Antagonists Enhancing Anti-PD-1 Antibody Therapy in Colorectal CancerThu,
Alkyl-Branched Acyl-Lysine Peptides as Potent Cell-Permeable Slow-Substrate Inhibitors of SIRT2Tue,