Key result
Intramyocardial high-frequency ablation in pigs creates non-transmural channels inducing local angiogenesis and functional LV communication.
Why the study?
Feasibility of creating non-transmural myocardial channels using intramyocardial high-frequency ablation and their long-term effects were not established in a large animal model.
Answers are grounded in this paper and cite their sources.
A previous study in rabbit hearts demonstrated the feasibility of creating transmyocardial channels by application of temperature-regulated high-frequency (HF) energy. Feasibility of creating non-transmural channels using a transvascular approach was tested in 14 pigs which were followed for 1 h, and 3 and 9 weeks (group A, B and C). Myocardial channels were found to be highly reproducible and patent in more than two thirds in group A. Channels were replaced by connective tissue during follow-up which contained newly formed small vessels. A functional communication between the left ventricular cavum and newly formed vessels of the channel remnants could be demonstrated in one heart of group C. Thus, intramyocardial HF ablation can be performed with high reproducibility to induce local angiogenesis.
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Dietz et al. (2003) studied this question. Intramyocardial high-frequency (HF) ablation was evaluated on Feasibility of creating non-transmural channels and inducing local angiogenesis. Intramyocardial high-frequency ablation in pigs reproducibly created non-transmural channels that induced local angiogenesis and functional communication with the left ventricular cavity.
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