Key result
Multimorbidity linked to ~193% higher risk of new-onset memory-related diseases.
Why the study?
The association between multimorbidity and memory-related diseases among Chinese middle-aged and older adults was not well established.
Does multimorbidity increase the risk of memory-related diseases in Chinese middle-aged and older adults?
Cohort (n=8,338)
Yes
Does multimorbidity increase the risk of memory-related diseases in Chinese middle-aged and older adults?
Multimorbidity is significantly associated with an increased risk of developing memory-related diseases in middle-aged and older adults, with the risk increasing with the severity of multimorbidity.
Answers are grounded in this paper and cite their sources.
Supports cognitive monitoring in multimorbid adults; leaves open causality and needs confirmation in diverse cohorts.
Objectives: This study aimed to examine the cross-sectional and longitudinal association between multimorbidity and memory-related diseases (MDs) among Chinese middle-aged and older adults. Methods: This study included 8,338 subjects who participated in the China Health and Retirement Longitudinal Study (CHARLS). Logistic regression and Cox proportional hazards regression models were used to explore the association and effect of multimorbidity on MDs. Results: The overall prevalence of MDs was 2.52%, and the mean multimorbidity number was 1.87. In a cross-sectional analysis, compared with the no multimorbidity group, groups of multimorbidity with four or more non-communicable diseases (NCDs) were more likely to have MDs (OR: 6.49, 95%CI: 4.35-9.68). Within 2.7 years of follow-up, 82 cases of MDs (1.12%) were reported, and participants with multimorbidity were more likely to have new-onset MDs than participants without multimorbidity (HR: 2.93, 95%CI: 1.74-4.96). Conclusion: Multimorbidity is associated with MDs among Chinese middle-aged and older adults. This relationship gradually strengthens with the severity of multimorbidity, which indicates that early prevention for people with multimorbidity may reduce the risk of MDs.
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Chen et al. (2023) conducted a cohort in Memory-related diseases (n=8,338). Multimorbidity vs. No multimorbidity was evaluated on New-onset memory-related diseases (MDs) (HR 2.93, 95% CI 1.74-4.96). Multimorbidity was associated with a higher risk of new-onset memory-related diseases compared to no multimorbidity over 2.7 years of follow-up (HR 2.93; 95% CI 1.74-4.96).
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