Key result
Indomethacin identically reduces GFR and HR while increasing MBP in glomerulonephritis patients and healthy controls.
Why the study?
The effects of indomethacin on renal function in normotensive patients with chronic glomerulonephritis and preserved renal function were not established.
Does indomethacin alter renal function and hemodynamics in normotensive patients with chronic glomerulonephritis with preserved renal function compared to healthy controls?
Does indomethacin alter renal function and hemodynamics in normotensive patients with chronic glomerulonephritis with preserved renal function compared to healthy controls?
Indomethacin causes similar acute hemodynamic and renal changes in normotensive patients with chronic glomerulonephritis with preserved renal function as in healthy controls, without an increased risk of acute renal deterioration.
Acute NSAID response identical in early GN and controls; leaves open long-term safety in larger prospective cohorts.
Thirteen normotensive patients with biopsy verified chronic glomerulonephritis (GN) with preserved renal function and 12 healthy control subjects (CS) were studied before and during prostaglandin synthesis inhibition by indomethacin. Glomerular filtration rate (GFR), renal plasma flow (RPF), urinary output (V), sodium excretion (UNa V), fractional lithium excretion (FELi), plasma levels of angiotensin II (Ang II), aldosterone (Aldo), atrial natiuretic peptide (ANP), arginine vasopressin (AVP) and endothelin (ir-ET) and urinary excretion rates of PGE2, mean blood pressure (MBP) and heart rate (HB) were determined on two separate occasions at least 7 days apart. During basal conditions without indomethacin administration no significant differences were found between the two groups. Indomethacin administration (100 mg 12 h and 1 h before clearance investigations) resulted in significant and almost identical decreases in GFR, RPF, V, UNa V, FELi and HR and increases in MBP in both the GN group and the CS group. It is concluded that normotensive patients with a biopsy verified chronic glomerulonephritis but with preserved renal function and without nephrotic syndrome have no increased risk of acute deterioration of renal function during administration of a non-steroidal anti-inflammatory drug compared with healthy control subjects.
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Nielsen et al. (1994) studied Chronic glomerulonephritis (n=25). Indomethacin vs. Healthy control subjects was evaluated on Renal function (GFR, RPF, V, UNa V, FELi) and hemodynamics (MBP, HR). Indomethacin caused significant and identical decreases in GFR, RPF, V, UNa V, FELi and HR, and increases in MBP in both chronic glomerulonephritis patients and healthy controls.
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