Key result
Two-hour aerobic exercise cuts intramyocellular lipids ~23% while increasing intrahepatocellular lipids.
Why the study?
The acute effect of aerobic exercise on intrahepatocellular lipids (IHCL) is unknown, and the relationship with exercise capacity, insulin sensitivity, and fat mass is unclear.
Does a 2-hour aerobic exercise alter intrahepatocellular and intramyocellular lipids in healthy subjects?
Comparison
Before and after 2-hours aerobic exercise at 50% VO2max
Design
Open-label cohort study using ¹H-MR-spectroscopy and hyperinsulinaemic euglycaemic clamp
Follow-up
2 hours
Authors
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Acute exercise may mobilize lipids differently by tissue in healthy subjects; leaves open relevance to metabolic disease or long-term outcomes.
Does a 2-hour aerobic exercise alter intrahepatocellular and intramyocellular lipids in healthy subjects?
p-value: p=<0.001
Acute aerobic exercise in healthy subjects decreases intramyocellular lipids but increases intrahepatocellular lipids.
Egger et al. (2013) studied Healthy Subjects (n=18). Aerobic exercise vs. Baseline (pre-exercise) was evaluated on Changes in intramyocellular (IMCL) and intrahepatocellular (IHCL) lipids from baseline (p=<0.001). A two-hour aerobic exercise at 50% of VO2max resulted in a significant decrease in intramyocellular lipids (-22.6%) and a significant increase in intrahepatocellular lipids (+34.9%) from baseline.