Key result
Higher plasma copeptin linked to ~86% greater odds of metabolic syndrome.
Why the study?
The association of plasma copeptin with components of the metabolic syndrome independently of insulin, diabetes mellitus, and environmental factors was unclear.
Is plasma copeptin associated with components of the metabolic syndrome independently of insulin, diabetes mellitus, and environmental factors?
Population
4742 subjects aged 46-68 years, 60% women, population-based sample in Malmö, Sweden
Comparison
Plasma copeptin quartiles with lowest quartile as reference
Design
Cross-sectional population-based study
Authors
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Copeptin should not yet inform MetS management; leaves open whether AVP modulation improves components beyond insulin and diabetes.
Cross-Sectional (n=4,742)
No
Is plasma copeptin associated with components of the metabolic syndrome independently of insulin, diabetes mellitus, and environmental factors?
Odds Ratio: 1.86
p-value: p=<0.001
Elevated plasma copeptin is independently associated with metabolic syndrome and its components, suggesting increased arginine vasopressin system activity may be a unifying factor in MetS.
Enhörning et al. (2011) conducted a cross-sectional in Metabolic syndrome (n=4,742). Plasma copeptin vs. Lowest quartile of plasma copeptin was evaluated on Metabolic syndrome (MetS) (OR 1.86, p=<0.001). Higher plasma copeptin levels were significantly associated with the metabolic syndrome (OR 1.86 for top vs lowest quartile; P<0.001) and its components, independent of insulin and diabetes.
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