Key result
Biventricular septal repair is linked to 0 residual shunts vs LV approach, with similar 30-day mortality.
Why the study?
Repair of postinfarction ventricular septal perforation is challenging with high risk of residual shunt and mortality, necessitating evaluation of a modified biventricular infarct exclusion technique.
Does a biventricular approach reduce mortality and residual shunts compared to a left ventricular approach in patients undergoing infarct exclusion for postinfarction ventricular septal perforation?
Cohort (n=33)
Randomized by operators
No
Does a biventricular approach reduce mortality and residual shunts compared to a left ventricular approach in patients undergoing infarct exclusion for postinfarction ventricular septal perforation?
Absolute Event Rate: 11% vs 21%
p-value: p=0.53
A biventricular approach for infarct exclusion in postinfarction ventricular septal perforation significantly reduces postoperative residual shunts compared to a left ventricular approach.
Biventricular infarct exclusion may eliminate residual shunts after postinfarction VSP repair; leaves open need for prospective validation before practice change.
Objectives: Repair of a postinfarction ventricular septal perforation (VSP) had been a difficult procedure with a high risk of postoperative residual shunt and subsequent mortality. This retrospective study aimed to assess a modified infarct exclusion technique with a biventricular approach. Methods: Thirty three consecutive patients who underwent the infarct exclusion procedure for VSP between 2002 and 2013 were reviewed. A biventricular approach (B group: 9 patients) and a left ventricular approach (L group: 24 patients) were analyzed. Results: The overall 30-day mortality of B and L group was 11%, and 21%, respectively, and there was not different between the two groups (p=0.53). No postoperative residual shunt was observed in the B group, however 8 cases in the L group (p=0.034). The overall five-year survival rate in the B and L group was 89% and 61%, respectively (p=0.19), however, the survival rate at five years revealed that significant difference between with and without residual VSP. Conclusion: The repair of post-infarction VSP can be safely performed by the infarct exclusion technique with a biventricular approach. This technique contributed to reduce surgical mortality and prevented recurrence of the VSP.
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Murakami et al. (2014) conducted a cohort in Post-infarction ventricular septal perforation (n=33). Biventricular approach (infarct exclusion technique) vs. Left ventricular approach was evaluated on 30-day mortality (p=0.53). The biventricular approach for post-infarction ventricular septal perforation repair resulted in a 30-day mortality of 11% compared to 21% with the left ventricular approach (p=0.53), and significantly eliminated postoperative residual shunts (0 vs 8 cases, p=0.034).
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