Key result
Intrauterine PCV2 infection linked to severe diffuse myocarditis, stillbirths, and late-term abortions in piglets.
Why the study?
The potential spectrum of disease associated with porcine circovirus 2 (PCV2) including vertical transmission and reproductive failure was not fully characterized.
Case Report
This report expands the potential spectrum of disease associated with PCV2 to include vertical transmission, reproductive failure, and fetal myocarditis in swine.
Answers are grounded in this paper and cite their sources.
May indicate vertical PCV2 transmission causing fetal myocarditis in swine; hypothesis-generating case report requiring prospective confirmation.
Porcine circovirus 2 (PCV2) is a recently identified agent that has been associated with postweaning multisystemic wasting syndrome (PMWS) in swine populations. In this report, the potential spectrum of disease associated with PCV2 is expanded by evidence of vertical transmission and associated reproductive failure. PCV2 was isolated from a litter of aborted piglets from a farm experiencing late-term abortions and stillbirths. Severe, diffuse myocarditis was present in 1 piglet associated with extensive immunohistochemical staining for PCV2 antigen. Variable amounts of PCV2 antigen were also present in liver, lung, and kidney of multiple fetuses. The presence of other agents that have been associated with fetal lesions and abortion in swine, including porcine parvovirus, porcine reproductive respiratory syndrome virus, encephalomyocarditis virus, and enterovirus, could not be established.
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West et al. (1999) conducted a case report in Porcine circovirus 2 (PCV2) infection in swine. Porcine circovirus 2 (PCV2) intrauterine infection was evaluated on Myocarditis and abortion. Intrauterine infection with Porcine circovirus 2 (PCV2) was associated with late-term abortions, stillbirths, and severe diffuse myocarditis in a litter of piglets.
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