Key result
Target-controlled propofol infusion achieves safe moderate sedation during prostate biopsy at ~1.5 mcg/mL.
Why the study?
The efficacy and safety of routine target-controlled infusion of propofol for sedation during transrectal ultrasound-guided prostate biopsy and the optimal sedation level were not established.
Does target-controlled propofol infusion provide safe and effective sedation in patients undergoing transrectal ultrasound-guided prostate biopsy?
RCT (n=250)
Randomized into five groups
Does target-controlled propofol infusion provide safe and effective sedation in patients undergoing transrectal ultrasound-guided prostate biopsy?
Target-controlled propofol infusion provides safe and effective sedation for transrectal ultrasound-guided prostate biopsy, with moderate sedation (OAA/S score 3) being optimal.
Supports deeper propofol TCI sedation to reduce discomfort in prostate biopsy; extends RCT dose-response data for procedural sedation.
The efficacy and safety of the routine use of target-controlled infusion of propofol for the sedation of patients undergoing transrectal ultrasound-guided prostate biopsy were assessed. The optimal level of sedation was also evaluated. A total of 250 patients were randomized into five groups according to sedation level determined by the Observer's Assessment of Alertness/Sedation (OAA/S) scale. As the level of sedation was increased, the overall pain and discomfort score decreased and the satisfaction rate tended to increase, although hypoxia meant that intervention occurred more frequently at higher sedation levels. Target-controlled infusion of propofol provided safe and effective sedation during transrectal ultrasound-guided prostate biopsy, particularly if moderate sedation (OAA/S score of 3) was achieved. The effect-site concentration of propofol for this level of sedation was about 1.5 microg/ml.
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Park et al. (2007) conducted an RCT in Transrectal ultrasound-guided prostate biopsy (n=250). Target-controlled infusion of propofol vs. Different sedation levels (five groups) was evaluated on Efficacy and safety (pain, discomfort, satisfaction, hypoxia). Target-controlled infusion of propofol provided safe and effective sedation during prostate biopsy, with moderate sedation achieved at an effect-site concentration of about 1.5 microg/ml.
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