Key result
Metabolic syndrome is linked to ~21% higher sdLDL-C levels.
Why the study?
The relationship between small dense LDL cholesterol levels measured by the heparin-magnesium precipitation method and metabolic syndrome in patients with coronary artery disease was evaluated.
Cross-Sectional (n=112)
No
Absolute Event Rate: 20.7% vs 17.1%
p-value: p=0.042
Small dense LDL cholesterol levels measured by the heparin-magnesium precipitation method are significantly elevated in CAD patients with metabolic syndrome and correlate with the number of metabolic syndrome components.
Elevated sd-LDL-C was associated with MetS in post-PCI CAD patients; leaves open its incremental value for risk stratification.
AIM: An evaluation of the relation between small dense low-density lipoprotein cholesterol (sd-LDL-C) levels measured by the heparin-magnesium precipitation method and metabolic syndrome (MetS). METHODS: We have prospectively measured sd-LDL-C levels by the heparin-magnesium precipitation method in 112 Japanese patients (male/female=80/32) with coronary artery disease (CAD) who received percutaneous coronary intervention (PCI). Patients were diagnosed with MetS according to modified Japanese criteria. RESULTS: A total of 36 patients (32%) met the criteria for MetS. Sd-LDL-C levels were significantly higher in the MetS group than non-MetS group (20.7 +/- 1.5 mg/dL vs. 17.1 +/- 1.0 mg/dL, p=0.042), especially among patients without lipid-lowering therapy (26.4 +/- 2.6 mg/dL vs. 17.5 +/- 1.5 mg/dL, p= 0.0034). Sd-LDL-C levels gradually increased with the number of components used to define MetS (0; 14.5 +/- 1.8 mg/dL, 1; 16.5 +/- 1.8 mg/dL, 2; 16.7 +/- 1.3 mg/dL, 3; 19.3 +/- 1.7 mg/dL, 4; 23.1 +/- 2.1 mg/dL, 5; 40.0 mg/dL, p=0.0071). High-sensitivity C-reactive protein (hs-CRP) levels were significantly higher in the patients with MetS (1.09 +/- 0.17 mg/L vs. 0.67 +/- 0.09 mg/L, p=0.0204). CONCLUSION: The sd-LDL-C level measured by the heparin-magnesium precipitation method is a useful marker of MetS in Japanese patients with CAD.
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Nozue et al. (2007) conducted a cross-sectional in Coronary Artery Disease (n=112). Metabolic syndrome vs. No metabolic syndrome was evaluated on Small dense low-density lipoprotein cholesterol (sd-LDL-C) levels (p=0.042). Metabolic syndrome was associated with significantly higher small dense LDL cholesterol levels compared to patients without metabolic syndrome (20.7 vs. 17.1 mg/dL, p=0.042).
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