Key result
Prompt anticoagulation and steroids rapidly resolve aortic valve thrombosis in idiopathic hypereosinophilic syndrome.
Why the study?
Cardiac thrombosis in idiopathic hypereosinophilic syndrome commonly involves ventricles or mitral and prosthetic valves, while aortic valve involvement is extremely rare.
Case Report (n=1)
Anticoagulant and steroid therapy can successfully treat rare aortic valve thrombosis in patients with idiopathic hypereosinophilic syndrome, preserving the native valve.
Answers are grounded in this paper and cite their sources.
May support medical therapy for aortic valve thrombosis in hypereosinophilic syndrome; leaves open need for prospective data before practice change.
Idiopathic hypereosinophilic syndrome (HES) is characterized by persistent eosinophilia and eosinophil-mediated organ-system damage. Cardiac thrombosis and thromboembolic complications represent common causes of morbidity and mortality and usually involve cardiac ventricles or mitral and prosthetic valves, while the involvement of the aortic valve is extremely rare in HES. Here we report peculiar multimodality images of an atypical case of extended thrombosis of the aortic valve, complicated by myocardial ischemia and asymptomatic cerebral ischemia, likely due to thrombus embolization, occurring in a 48-year-old man with HES. Prompt anticoagulant and steroid therapy lead to rapid and complete resolution of the thrombotic lesions, allowing preserving the native valve and preventing further embolic events.
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Grolla et al. (2015) conducted a case report in Idiopathic hypereosinophilic syndrome (HES) with aortic valve thrombosis (n=1). Anticoagulant and steroid therapy was evaluated on Resolution of thrombotic lesions. Prompt anticoagulant and steroid therapy led to rapid and complete resolution of aortic valve thrombosis in a 48-year-old man with idiopathic hypereosinophilic syndrome.
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