Key result
A diet high in meat and alcohol is linked to increased carotid-femoral PWV.
Why the study?
Few studies have examined the association between global diet assessed through dietary patterns and arterial structure and function.
Do specific dietary patterns affect arterial stiffness, carotid intima-media thickness, and atherosclerosis in middle-aged adults?
Cohort (n=1,026)
Do specific dietary patterns affect arterial stiffness, carotid intima-media thickness, and atherosclerosis in middle-aged adults?
Absolute Event Rate: 11.58% vs 11.15%
p-value: p=0.03
A nutritionally poor diet characterized by high meat and alcohol intake and low micronutrient intake is associated with increased large artery stiffness over 7.5 years.
Supports association of poor diet with arterial stiffness; hypothesis-generating and requires RCTs before informing practice.
BACKGROUND: Few studies have examined the association between global diet, assessed through dietary patterns, and arterial structure and function. The aim of this study was to investigate the relationship between carotid-femoral pulse-wave velocity (PWV), common carotid-arteries intima-media thickness (CCA-IMT) and plaques with dietary patterns measured 7.5 years earlier. DESIGN: A prospective cohort study between diet and markers of structure and function of large arteries. METHODS: Dietary patterns (linear combination of food consumption) were identified using principal component analysis among 1026 middle-aged participants in the SUpplémentation en VItamines et Minéraux AntioXydants (SU.VI.MAX) vascular substudy. Dietary data were based on repeated 24-h dietary records (at least three records during 2 years) obtained at inclusion. Carotid-femoral PWV was used to assess aortic stiffness. Carotid ultrasound examination included measurements of CCA-IMT and carotid plaques. RESULTS: Four dietary patterns were identified. In multivariate models, a significant positive association was observed between PWV and a dietary pattern positively correlated with meat and alcohol consumption and negatively correlated with fibers, vitamins B9 and C, β-carotene and calcium consumption. Adjusted PWV mean across tertiles of this pattern score was 11.15, 11.26 and 11.58 m/s in the first, second and third tertiles, respectively (P for trend=0.03). Others dietary patterns were not associated with PWV and we detected no association between dietary patterns and IMT or plaques. CONCLUSION: This study suggests that a nutritionally poor dietary pattern, characterized by a high meat and alcohol consumption and low micronutrients intake, is related to an increased stiffening of large arteries.
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Kesse‐Guyot et al. (2010) conducted a cohort in Arterial stiffness and atherosclerosis (n=1,026). Dietary pattern high in meat and alcohol and low in micronutrients vs. Lower adherence to this dietary pattern (first tertile) was evaluated on Carotid-femoral pulse-wave velocity (PWV) (p=0.03). A dietary pattern high in meat and alcohol and low in micronutrients was associated with increased carotid-femoral pulse-wave velocity (11.58 m/s in highest vs 11.15 m/s in lowest tertile; P=0.03).
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