Key result
Single-dose HB-SOD markedly inhibits induced paw and brain edema in rats.
Why the study?
Enzymes degrading reactive oxygens like superoxide dismutase are significantly lower in plasma than intracellular compartments, necessitating protection of endothelial cell surfaces against oxidative stress.
Does a single dose of HB-SOD reduce carrageenin-induced paw edema and cold-induced brain edema in rat models?
Population
Cultured endothelial cells and rat models of carrageenin-induced paw edema and cold-induced brain edema
Comparison
HB-SOD treatment vs no treatment or control conditions
Design
Preclinical experimental study
Authors
Loading...
Supports endothelial-targeted SOD for vasogenic edema; leaves open human translation.
Does a single dose of HB-SOD reduce carrageenin-induced paw edema and cold-induced brain edema in rat models?
Targeting superoxide dismutase to the endothelial cell surface via a novel heparin-binding fusion protein (HB-SOD) effectively inhibits vasogenic edema in rat models.
Inoue et al. (1990) studied Carrageenin-induced paw edema and cold-induced brain edema. HB-SOD (fusion gene of human Cu2+/Zn2(+)-SOD and heparin-binding peptide) was evaluated on Carrageenin-induced paw edema and cold-induced brain edema. A single dose of HB-SOD markedly inhibited carrageenin-induced paw edema and cold-induced brain edema in rats.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: