Use of combination of olmesaratan with lercanidipine for endothelial dysfunction correction in patient with essential hypertension

The clinical case of essential hypertension patient pharmacotherapy using the combination of olmesartan with lercanidipine was described in the article. The authors evaluated the effect of this combination not only on the degree of lowering blood pressure, but also on the levels of markers of endothelial dysfunction such as sPECAM-1 and copeptin. Pharmacotherapy with this combination of medicines was carried out for 28 weeks. It was found that in this patient the combination of olmesartan with lercanidipine led to the achievement of the blood pressure target level and decrease the level of sPECAM-1 by 2.5 times, and the level of copeptin by 5 times compared with the initial levels before treatment. Thus, the authors concluded that the combination of olmesartan and lercanidipine not only leads to the normalization of blood pressure, but also reduces the severity of endothelial dysfunction, which underlies the pathogenesis of essential hypertension.