Key result
The fixed-dose combination of lercanidipine and enalapril facilitates a marked reduction in blood pressure, providing additional benefits in organ protection and reduced adverse effects.
Why the study?
Does the combination of lercanidipine and enalapril improve blood pressure control and organ protection in patients with arterial hypertension?
Does the combination of lercanidipine and enalapril improve blood pressure control and organ protection in patients with arterial hypertension?
The fixed-dose combination of lercanidipine and enalapril offers effective blood pressure reduction and organ protection, particularly in elderly, diabetic, or obese patients.
May support lercanidipine-enalapril combination in select hypertensive patients; hypothesis-generating for organ protection, needing randomized confirmation.
This review presents the evidence on the benefits of fixed-dose combination therapy for arterial hypertension management. The focus is on the combination of a third-generation dihydropyridine calcium antagonist lercanidipine and an ACE inhibitor enalapril. Lercanidipine is characterised by high vascular selectivity and lipophilicity, good antihypertensive effectiveness, and prolonged, gradually developing therapeutic effects. Literature data on the effectiveness of the lercanidipine-enalapril combination are presented. This combination facilitates a marked reduction in blood pressure levels, which is particularly relevant for elderly patients and patients with diabetes mellitus or obesity. The combination of pharmacologic effects of lercanidipine and enalapril provides additional benefits in terms of organ protection and reduction of adverse effects of the antihypertensive treatment.
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Л. О. Минушкина (2013) conducted a review in arterial hypertension. Lercanidipine and enalapril combination was evaluated on Blood pressure reduction. The fixed-dose combination of lercanidipine and enalapril facilitates a marked reduction in blood pressure, providing additional benefits in organ protection and reduced adverse effects.
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