Key result
One week of human growth hormone raises triglycerides ~30% in nondiabetics, driven by VLDL-2 increases.
Why the study?
The impact of moderately elevated human growth hormone concentrations, as seen in insulin dependent diabetic patients, on plasma lipoproteins was unclear.
Does human growth hormone administration increase plasma lipoprotein concentrations in nondiabetic persons?
Does human growth hormone administration increase plasma lipoprotein concentrations in nondiabetic persons?
Absolute Event Rate: 1.27% vs 0.98%
Short-term administration of human growth hormone in nondiabetic individuals significantly increases total plasma triglycerides and atherogenic VLDL-2 remnants.
No takes yet. Share an insight, caveat, or question.
May warrant lipid monitoring with short-term HGH; hypothesis-generating and should not yet change practice.
Møller et al. (1989) studied Nondiabetic persons. Human growth hormone vs. Baseline (before treatment) was evaluated on Total plasma triglyceride. One week of human growth hormone treatment in nondiabetic persons significantly raised total plasma triglyceride from 0.98 mmol/l to 1.27 mmol/l, driven by increases in VLDL-2 fractions.
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