Key result
High-dose citalopram and escitalopram linked to ~46% greater OHCA risk versus sertraline.
Why the study?
Conflicting results have been reported regarding the association between antidepressant use and out-of-hospital cardiac arrest risk.
Does the use of specific antidepressants increase the risk of out-of-hospital cardiac arrest compared to reference antidepressants?
Population
10,987 OHCA cases from presumed cardiac causes in a nationwide nested case-control study
Comparison
Individual antidepressant drugs versus reference drugs within the same class
Design
Nationwide nested case-control study
Follow-up
2001 to 2015
Authors
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High-dose citalopram, escitalopram, and mirtazapine were associated with higher OHCA rates; leaves open need for prospective confirmation before changing prescribing.
Case-Control (n=10,987)
Yes
Does the use of specific antidepressants increase the risk of out-of-hospital cardiac arrest compared to reference antidepressants?
Hazard Ratio: 1.46 (95% CI 1.27–1.69)
High-dose citalopram, escitalopram, and mirtazapine are associated with an increased risk of out-of-hospital cardiac arrest, highlighting the need for careful dose titration.
Eroglu et al. (2022) conducted a case-control in Out-of-hospital cardiac arrest (n=10,987). Antidepressant drugs vs. Sertraline, duloxetine, and amitriptyline was evaluated on Out-of-hospital cardiac arrest (HR 1.46, 95% CI 1.27-1.69). High-dose citalopram (>20 mg) and escitalopram (>10 mg) were associated with increased out-of-hospital cardiac arrest risk compared to sertraline (HR 1.46; 95% CI 1.27-1.69 for citalopram).
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