Key result
IV magnesium sulfate cuts post-cardiac surgery arrhythmias ~50% versus placebo.
Why the study?
Arrhythmia, postoperative pain, and agitation are common complications after cardiac surgery that contribute to morbidity and mortality, motivating evaluation of magnesium sulfate efficacy.
Does magnesium sulfate reduce post cardiac surgery arrhythmia, pain, and agitation in adult patients undergoing elective cardiac surgery?
RCT (n=140)
Double-blind
Computer-generated random number
Yes
Does magnesium sulfate reduce post cardiac surgery arrhythmia, pain, and agitation in adult patients undergoing elective cardiac surgery?
Magnesium sulfate administration significantly reduces the incidence of postoperative arrhythmias and pain severity in patients undergoing elective cardiac surgery.
Answers are grounded in this paper and cite their sources.
IV magnesium prophylaxis merits consideration in elective cardiac surgery; confirms arrhythmia reduction in this RCT.
Background: Arrhythmia, postoperative pain and agitation are a common complication after heart surgery and are a major source of morbidity and mortality.Aims: This study aimed to study the efficacy of magnesium sulfate (MgSO 4 ) for reduction of post cardiac surgery arrhythmia, postoperative pain and agitation. Setting and Design: This study design was a prospective randomized controlled double blinded clinical study.Patients and Methods: 140 adult patients that underwent elective cardiac surgery were randomized into 2 groups, Mg group (group magnesium), 70 patients received 30 mg.kg -1 MgSO 4 in 500 cc normal saline and in group C (control group), 70 patients received 500 cc normal saline alone. Statistical Analysis used: Mann-Whitney's, Chi square, Friedman's, factorial ANOVA, logistic and multiple regression analysis were used.Results: Comparative study between the 2 groups revealed; significant decrease in arrhythmia events in Mg group; compared to control group; with significant statistical difference (p=0.023).The 2 groups showed marked decrease in VAS scores in Mg group; compared to control group; during the serial measurements.Comparative study between the 2 groups revealed non-significant difference as regards RASS score (p>0.05).Conclusion: Mg significantly decreases the incidence of all type of postcardiac surgery arrhythmia and decrease the severity of postoperative pain and agitation.
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Hamed et al. (2018) conducted an RCT in Elective cardiac surgery with cardiopulmonary bypass (n=140). Magnesium sulfate vs. 500 cc normal saline (placebo) was evaluated on Incidence of post cardiac surgery arrhythmias (p=0.023). Intravenous magnesium sulfate significantly reduced the incidence of post-cardiac surgery arrhythmias compared to placebo (18.6% vs 37.1%, p=0.023).
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