Intra- and interpopulation skin grafting together with an analysis of antigen sharing involving third-party test grafts reveal that: (1) there is widespread sharing of histocompatibility antigens among newts (Diemictylus) from several geographical locations; (2) there is a substantial diversity of histocompatibility genes distinguishing individuals within each population; (3) there is no “strong” H-2 type of complex locus involved in graft rejection in newts from any of the populations analyzed; and (4) allograft rejection, even when relatively rapid, is referable to multiple “weak” histocompatibility genes which may have cumulative effects. The high incidence of acute and subacute rejections found in one population indicates that the chronic reactions characteristic of this species are not attributable to a deficient immune response capacity.
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Cohen et al. (1968) studied this question.