Objective: The aim of our study was to test the protective effect of pumpkin seed oil against sodium nitrite toxicity in rats.Methods: Forty eight adult male albino rats were divided into 4 groups.The rats were administered daily 100 mg/kg/day sodium nitrite in presence/absence of 1.5 ml/kg/day pumpkin seed oil for 5 weeks. Results:The results indicated that sodium nitrite induced oxidative stress, lipids profile disorders, DNA damage and chromosomal abnormalities.The pumpkin seed oil has antioxidant effect; it improved levels of total antioxidant capacity, malondialdehyde and lipids profile.It also has antimutagenic effect; it decreased the DNA damage and structural chromosomal abnormalities.Conclusion: Pumpkin seed oil can ameliorate the toxic effects induced by sodium nitrite.
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DM et al. (2017) studied this question.
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