Key result
Population pharmacokinetic modeling revealed a 57% lower metoprolol clearance rate in geriatric women compared to geriatric men, suggesting that equivalent systemic exposure requires gender-stratified dosing.
Why the study?
Does gender affect the pharmacokinetics of metoprolol in elderly patients, and what are the equivalent doses?
Population
n=7 chronically-ill geriatric inpatients with multiple comorbidities, mean age 75 ± 9 years, mean body…
Comparison
Metoprolol 50 mg single oral dose followed by… vs Healthy young CYP2D6 Extensive Metabolizers.
Design
Other
Follow-up
24 hours (simulation)
Authors
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May warrant cautious metoprolol dosing in geriatric women; leaves open prospective validation before practice change.
Does gender affect the pharmacokinetics of metoprolol in elderly patients, and what are the equivalent doses?
Effect estimate: 57.2% increase in males
Absolute Event Rate: 59.1% vs 105%
p-value: p=2.70E-5
Gender-stratified dosing of metoprolol (15 mg for geriatric women, 25 mg for geriatric men) is required to achieve equivalent systemic exposure to a 50 mg dose in healthy young males due to a 57% lower clearance rate in elderly women.
Eugene AR (2016) studied Multiple comorbidities (n=7). Metoprolol vs. Geriatric males (for gender comparison) was evaluated on Apparent Clearance (CL) (57.2% increase in males, p=2.70E-5). Population pharmacokinetic modeling revealed a 57% lower metoprolol clearance rate in geriatric women compared to geriatric men, suggesting that equivalent systemic exposure requires gender-stratified dosing.
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