Why the study?
Does metoprolol 100 mg daily improve tolerability without compromising efficacy compared to 200 mg daily in patients aged 65 years or older with moderate hypertension?
Does metoprolol 100 mg daily improve tolerability without compromising efficacy compared to 200 mg daily in patients aged 65 years or older with moderate hypertension?
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Metoprolol 100 mg daily is the preferred dose for older patients with moderate hypertension due to equal efficacy and better tolerability compared to 200 mg daily.
Thirty-one patients aged 65 y or over suffering from moderate hypertension were studied for 16 weeks using a cross-over design in which metoprolol 100 mg daily and metoprolol 200 mg daily were compared. Both treatment regimes were effective in controlling hypertension and no difference was found between the two with regard to efficacy. The 100 mg regime was, however, better tolerated and we propose this as the preferred metoprolol dose for the aged hypertensive.
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Martin et al. (1985) studied this question.
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