Why the study?
Does atenolol compared to metoprolol improve blood pressure and heart rate in patients with mild or moderate essential hypertension?
Population
n=13 patients (9 men, 4 women, aged 37-67 years) with mild or moderate essential hypertension.
Comparison
Atenolol 50, 100, and 200 mg given once daily. vs Metoprolol 50, 100, and 200 mg given once daily.
Design
RCT, randomized cross-over, open
Authors
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Atenolol 50 mg once daily may achieve maximal BP reduction in mild hypertension while metoprolol requires 100 mg; extends dose-response data for beta-blocker selection.
Does atenolol compared to metoprolol improve blood pressure and heart rate in patients with mild or moderate essential hypertension?
Atenolol 50 mg and metoprolol 100 mg once daily are effective for mild or moderate hypertension, with higher doses providing no additional blood pressure reduction.
Rasmussen et al. (1981) studied this question.
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