What question did this study set out to answer?

To compare the 24-hour antihypertensive and heart rate-lowering efficacy of once-daily atenolol versus standard and sustained-release metoprolol.

June 19, 1982BMJOpen Access

Atenolol and metoprolol once daily in hypertension

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Why the study?

Does once-daily atenolol or metoprolol improve blood pressure and heart rate control in hypertensive outpatients?

Population

9 carefully selected hypertensive outpatients

Comparison

Atenolol 50 mg/day, atenolol 100 mg/day… vs Active comparators

Design

RCT, randomised sequence

Follow-up

3 weeks per treatment

Authors

ASA K ScottUniversity of Aberdeen JWJ WebsterUniversity of Aberdeen GHG M HawksworthUniversity of Aberdeen

Discussion

Member takes

Implication

May favor atenolol over metoprolol for once-daily hypertension control; extends comparative beta-blocker duration data.

Key Points

To compare the 24-hour antihypertensive and heart rate-lowering efficacy of once-daily atenolol versus standard and sustained-release metoprolol.
Randomized trial conducted in N=9 selected hypertensive outpatients.
Patients received atenolol 50 mg/day, atenolol 100 mg/day, standard metoprolol 100 mg/day, and sustained-release metoprolol 200 mg/day in a randomized sequence.
Each treatment regimen was administered once daily for three weeks, with blood pressure and heart rate measured 24 hours after dosing.
Twenty-four hours after dosing, no important differences in blood pressure or heart rate control were observed between atenolol 50 mg/day and 100 mg/day.
Both standard metoprolol (100 mg/day) and sustained-release metoprolol (200 mg/day) demonstrated limitations in sustaining systolic blood pressure and heart rate control throughout the 24-hour dosing interval.

Structured PICO

Does once-daily atenolol or metoprolol improve blood pressure and heart rate control in hypertensive outpatients?

Population

9 carefully selected hypertensive outpatients

Intervention

Atenolol 50 mg/day, atenolol 100 mg/day, metoprolol 100 mg/day, and metoprolol 200 mg/day (sustained-release formulation) given once daily

Comparator

Active comparators (crossover design where each patient received all treatments in a randomised sequence)

Outcome

Systolic blood pressure and heart rate control 24 hours after dosingsurrogate

Once-daily atenolol appears to provide more consistent 24-hour control of systolic blood pressure and heart rate compared to once-daily metoprolol in hypertensive patients.

Cite This Study

Scott et al. (1982) studied this question.

synapsesocial.com/papers/6a942defbeaf7a0a159c5d97 https://doi.org/10.1136/bmj.284.6332.1873-c

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Atenolol and metoprolol once daily in hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Atenolol and metoprolol once daily in hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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