Why the study?
Does once-daily atenolol reduce blood pressure and alter haemodynamics compared to baseline and metoprolol in patients with essential hypertension?
Does once-daily atenolol reduce blood pressure and alter haemodynamics compared to baseline and metoprolol in patients with essential hypertension?
Once-daily atenolol effectively lowers blood pressure over 24 hours and produces haemodynamic changes, including reduced cardiac index, comparable to multiple daily doses of metoprolol.
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May support once-daily atenolol for BP control in hypertension; leaves open comparative efficacy versus metoprolol in randomized trials.
Tsukiyama et al. (1980) studied this question.
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