Why the study?
Does once-daily atenolol reduce 24-hour ambulatory blood pressure in patients with newly diagnosed untreated hypertension?
Does once-daily atenolol reduce 24-hour ambulatory blood pressure in patients with newly diagnosed untreated hypertension?
Once-daily atenolol significantly reduces 24-hour intraarterial ambulatory blood pressure in patients with newly diagnosed hypertension.
May support once-daily atenolol for 24-h BP control in new hypertension; hypothesis-generating and should not yet change practice.
We measured intraarterial, ambulatory blood pressure over a 24-h period in 12 subjects 24--63 years (mean 47.6) of age with newly diagnosed untreated hypertension. Measurements were performed both before and after 2--9 months of once-daily treatment with atenolol, a cardioselective beta-adrenoceptor antagonist. Significant reductions in arterial pressure (p less than 0.005) during treatment with atenolol (dose range 50--200 mg) were observed over the full 24-h period.
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Floras et al. (1981) studied this question.
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