Why the study?
Does atenolol administered once daily reduce blood pressure in patients with primary hypertension, and is there a difference between 100 mg and 200 mg doses?
Does atenolol administered once daily reduce blood pressure in patients with primary hypertension, and is there a difference between 100 mg and 200 mg doses?
Atenolol administered once daily effectively reduces blood pressure in primary hypertension, with the 100 mg dose being as effective as the 200 mg dose.
Atenolol once daily was associated with BP reduction without 100 vs 200 mg differences; leaves open randomized confirmation of dose equivalence.
The antihypertensive effect on the selective beta-1-adrenoceptor blocking agent, atenolol, given in doses of 100 and 200 mg once daily, was evaluated in 37 patients with primary hypertension. The drug induced an efficient reduction of BP, and in the whole patient series there was no difference in BP on either dosage. Exercise tests, performed in 10 patients, showed the same degree of partial beta-blockade 24 hours after intake of 100 and 200 mg atenolol. PRA decreased during treatment with atenolol but there was no correlation between the stimulated pretreatment renin level and the antihypertensive effect of atenolol. Side-effects were few and 35 out of 37 patients continued on atenolol treatment. Central nervous side-effects were not seen.
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Nilsson et al. (1979) studied this question.
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