Key result
Atenolol at doses of 25, 50, or 100 mg daily for 4 weeks showed a relatively flat plasma concentration-antihypertensive response relationship, with no clear optimum daily dose identified.
Why the study?
Does a higher dose of atenolol (50 or 100 mg) improve the antihypertensive response compared to 25 mg in patients with mild-to-moderate essential hypertension?
RCT
Double-blind
randomized
Does a higher dose of atenolol (50 or 100 mg) improve the antihypertensive response compared to 25 mg in patients with mild-to-moderate essential hypertension?
In patients with mild-to-moderate hypertension, atenolol doses of 25, 50, and 100 mg daily produce a relatively flat antihypertensive response, suggesting lower doses may be similarly effective to higher doses.
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Supports initiating atenolol at 25 mg daily for mild-to-moderate hypertension; confirms flat dose-response in this RCT.
Ishizaki et al. (1983) conducted an RCT in mild-to-moderate essential hypertension. atenolol vs. different doses (25, 50, 100 mg) was evaluated on antihypertensive response, degree of beta-adrenoceptor blockade, and change in plasma renin activity. Atenolol at doses of 25, 50, or 100 mg daily for 4 weeks showed a relatively flat plasma concentration-antihypertensive response relationship, with no clear optimum daily dose identified.
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