Why the study?
Does the blood level of atenolol correlate with the degree of cardiac beta blockade and antihypertensive effect in hypertensive patients?
Does the blood level of atenolol correlate with the degree of cardiac beta blockade and antihypertensive effect in hypertensive patients?
Atenolol blood levels correlate with the degree of beta blockade (heart rate reduction) but not closely with blood pressure reduction in hypertensive patients.
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May inform atenolol dosing for beta blockade via levels but not BP response; leaves open PK/PD relationships in hypertension.
Amery et al. (1977) studied this question.
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