Why the study?
Does a fixed-dose combination of metoprolol and hydrochlorothiazide effectively reduce blood pressure and is it well tolerated in patients with mild to moderate hypertension, particularly the elderly?
Does a fixed-dose combination of metoprolol and hydrochlorothiazide effectively reduce blood pressure and is it well tolerated in patients with mild to moderate hypertension, particularly the elderly?
A fixed-dose combination of metoprolol and hydrochlorothiazide effectively reduces blood pressure across age groups, though elderly patients may have higher rates of treatment withdrawal due to side effects.
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Supports comparable BP reductions across ages yet higher elderly withdrawals merit caution; leaves open randomized evaluation of net benefit.
Goodfellow et al. (1981) studied this question.
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