Why the study?
Does metoprolol 100 mg daily (with optional low-dose hydrochlorothiazide) improve blood pressure response and safety compared to hydrochlorothiazide 25 mg daily in elderly hypertensive patients?
Does metoprolol 100 mg daily (with optional low-dose hydrochlorothiazide) improve blood pressure response and safety compared to hydrochlorothiazide 25 mg daily in elderly hypertensive patients?
In elderly hypertensive patients, starting treatment with metoprolol 100 mg daily is as effective as hydrochlorothiazide 25 mg daily but causes significantly less hypokalemia and hyperuricemia.
Authors
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Metoprolol offers a safer initial option than hydrochlorothiazide in elderly hypertension; extends randomized evidence supporting beta-blocker preference in this population.
John Wikstrand (1986) studied this question.
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