Key result
Hydrochlorothiazide 25 mg achieved similar blood pressure control compared to 50 mg (78% vs 89%) in elderly patients with isolated systolic hypertension, with less serum potassium reduction.
Why the study?
Does a lower dose (25 mg) of hydrochlorothiazide effectively reduce blood pressure with fewer side effects compared to a higher dose (50 mg) in elderly patients with isolated systolic hypertension?
RCT (n=51)
Double-blind
Yes
Does a lower dose (25 mg) of hydrochlorothiazide effectively reduce blood pressure with fewer side effects compared to a higher dose (50 mg) in elderly patients with isolated systolic hypertension?
Absolute Event Rate: 78% vs 89%
Hydrochlorothiazide 25 mg once daily is effective and well-tolerated for isolated systolic hypertension in the elderly, offering similar blood pressure control with less hypokalemia compared to the 50 mg dose.
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Supports 25 mg hydrochlorothiazide in elderly isolated systolic hypertension to minimize hypokalemia; confirms similar efficacy to 50 mg in RCT.
William C. Cushman (1991) conducted an RCT in isolated systolic hypertension (n=51). hydrochlorothiazide vs. hydrochlorothiazide 50 mg was evaluated on proportion of patients in whom blood pressure was controlled. Hydrochlorothiazide 25 mg achieved similar blood pressure control compared to 50 mg (78% vs 89%) in elderly patients with isolated systolic hypertension, with less serum potassium reduction.
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